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dc.contributor.authorLemme-Dumit, Jose M
dc.date.accessioned2020-08-07T14:55:20Z
dc.date.available2020-08-07T14:55:20Z
dc.date.issued2020-07-29
dc.identifier.urihttp://hdl.handle.net/10713/13501
dc.description.abstractJose Lemme-Dumit works in the field of mucosal immunology and vaccines. In this mSphere of Influence article, he reflects on how two papers, "Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium" by Sato et al. (T. Sato, D. E. Stange, M. Ferrante, R. G. J. Vries, et al., Gastroenterology 141:1762-1772, 2011, https://doi.org/10.1053/j.gastro.2011.07.050) and "T helper cell cytokines modulate intestinal stem cell renewal and differentiation" by Biton et al. (M. Biton, A. L. Haber, N. Rogel, G. Burgin, et al., Cell 175:1307-1320.E22, 2018, https://doi.org/10.1016/j.cell.2018.10.008), have influenced his research by describing the development of intestinal organoid cultures and implementation of high-throughput sequencing analysis. The combination of these forefront technologies has expanded opportunities for mechanistic interrogation of host immunity to enteric pathogens. Copyright © 2020 Lemme-Dumit.en_US
dc.description.urihttps://doi.org/10.1128/mSphere.00722-20en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofmSphereen_US
dc.rightsCopyright © 2020 Lemme-Dumit.en_US
dc.subjectenteroiden_US
dc.subjectimmune cellsen_US
dc.subjectmucosal immunologyen_US
dc.subjectsingle-cell sequencingen_US
dc.titlemSphere of Influence: Organoids and Single-Cell Sequencing, a Powerful Combination To Uncover Epithelial and Immune Cell Interactions in the Human Gut Environmenten_US
dc.typeArticleen_US
dc.identifier.doi10.1128/mSphere.00722-20
dc.identifier.pmid32727865
dc.source.volume5
dc.source.issue4
dc.source.countryUnited States


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