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    Overview of the Nontyphoidal and Paratyphoidal Salmonella Vaccine Pipeline: Current Status and Future Prospects

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    Author
    Baliban, Scott M
    Lu, Ying-Jie
    Malley, Richard
    Date
    2020-08-15
    Journal
    Clinical Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/cid/ciaa514
    Abstract
    Nontyphoidal Salmonella and Salmonella Paratyphi are responsible for significant morbidity and mortality worldwide. To date, no vaccine has been licensed against these organisms. The development of effective vaccines remains an urgent priority. In this review, the rationale for and current status of various vaccine candidates against S. Paratyphi and nontyphoidal Salmonella are presented, with a focus on the research findings from the 2019 International Conference on Typhoid and Other Invasive Salmonelloses. Additionally, other vaccine candidates that are currently undergoing clinical development are highlighted. Future approaches, which may include antigens that are genetically conserved across Salmonella and confer broad, non–serotype-specific protection, are also discussed.
    Rights/Terms
    © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
    Keyword
    Salmonella
    NTS
    Paratyphi
    vaccines
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13500
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciaa514
    Scopus Count
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    UMB Open Access Articles 2020

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