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dc.contributor.authorLiu, Minxuan
dc.contributor.authorGalli, Gina
dc.contributor.authorWang, Yilin
dc.contributor.authorFan, Qiru
dc.contributor.authorWang, Zhenzhong
dc.contributor.authorWang, Xin
dc.contributor.authorXiao, Wei
dc.date.accessioned2020-08-06T17:11:15Z
dc.date.available2020-08-06T17:11:15Z
dc.date.issued2020-07-15
dc.identifier.urihttp://hdl.handle.net/10713/13492
dc.description.abstractInsufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways. Therefore, it is hypothesized that HIF represents a potential therapeutic target for the treatment and prevention of cardiovascular diseases. In this short review, we introduce the pathophysiology of hypoxic injury in cardiovascular disease, and we conclude from convincing evidence that HIF can modulate relevant cardioprotective signaling pathways. © Copyright © 2020 Liu, Galli, Wang, Fan, Wang, Wang and Xiao.en_US
dc.description.urihttps://doi.org/10.3389/fphys.2020.00774en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Physiologyen_US
dc.subjectatherosclerosisen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectHIFen_US
dc.subjecthypoxiaen_US
dc.subjectmyocardial infarctionen_US
dc.subjecttherapeutic targeten_US
dc.titleNovel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fphys.2020.00774
dc.identifier.scopusidSCOPUS_ID:85088791112
dc.source.volume11


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