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    Novel Therapeutic Targets for Hypoxia-Related Cardiovascular Diseases: The Role of HIF-1

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    Author
    Liu, Minxuan
    Galli, Gina
    Wang, Yilin
    Fan, Qiru
    Wang, Zhenzhong
    Wang, Xin
    Xiao, Wei
    Date
    2020-07-15
    Journal
    Frontiers in Physiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fphys.2020.00774
    Abstract
    Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosphorylation. Hypoxia-inducible factor (HIF) is activated in hypoxic conditions and acts as an important modulator of diverse target genes in the human body. The downstream genes of HIF include vital modulators of cardiovascular-related signaling pathways. Therefore, it is hypothesized that HIF represents a potential therapeutic target for the treatment and prevention of cardiovascular diseases. In this short review, we introduce the pathophysiology of hypoxic injury in cardiovascular disease, and we conclude from convincing evidence that HIF can modulate relevant cardioprotective signaling pathways. © Copyright © 2020 Liu, Galli, Wang, Fan, Wang, Wang and Xiao.
    Keyword
    atherosclerosis
    cardiovascular disease
    HIF
    hypoxia
    myocardial infarction
    therapeutic target
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13492
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphys.2020.00774
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