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dc.contributor.authorZorlu, Yunus
dc.contributor.authorBrown, Connor
dc.contributor.authorKeil, Claudia
dc.contributor.authorAyhan, M. Menaf
dc.contributor.authorHaase, Hajo
dc.contributor.authorThompson, Richard B.
dc.contributor.authorLengyel, Imre
dc.contributor.authorYücesan, Gündoğ
dc.description.abstractHerein, we report the third generation of fluorescent probes (arylphosphonic acids) to target calcifications, particularly hydroxyapatite (HAP). In this study, we use highly conjugated porphyrin-based arylphosphonic acids and their diesters, namely 5,10,15,20-tetrakis[m-(diethoxyphosphoryl)phenyl]porphyrin (m-H8TPPA-OEt8) and 5,10,15,20-tetrakis [m-phenylphosphonic acid]porphyrin (m-H8TPPA), in comparison with their positional isomers 5,10,15,20-tetrakis[p-(diisopropoxyphosphoryl)phenyl]porphyrin (p-H8TPPA-iPr8) and 5,10,15,20-tetrakis [p-phenylphosphonic acid]porphyrin (p-H8TPPA), which have phosphonic acid units bonded to sp2 carbon atoms of the fluorescent core. The conjugation of the fluorescent core is thus extended to the (HAP) through sp2-bonded −PO3H2 units, which generates increased fluorescence upon HAP binding. The resulting fluorescent probes are highly sensitive towards the HAP in rat bone sections. The designed probes are readily taken up by cells. Due to the lower reported toxicity of (p-H8TPPA), these probes could find applications in monitoring bone resorption or adsorption, or imaging vascular or soft tissue calcifications for breast cancer diagnosis etc. © 2020 The Authors.en_US
dc.description.sponsorshipDeutsche Forschungsgemeinschaften_US
dc.relation.ispartofChemistry - A European Journalen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectfluorescent imagingen_US
dc.subjectligand synthesisen_US
dc.subjectvascular calcificationsen_US
dc.titleFluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Coreen_US

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