Association of Influenza Activity and Environmental Conditions With the Risk of Invasive Pneumococcal Disease
Tuite, Ashleigh R
Harris, Anthony D
Fisman, David N
JournalJAMA network open
PublisherAmerican Medical Association
MetadataShow full item record
AbstractImportance: Streptococcus pneumoniae is the most commonly identified cause of bacterial pneumonia, and invasive pneumococcal disease (IPD) has a high case fatality rate. The wintertime coseasonality of influenza and IPD in temperate countries has suggested that pathogen-pathogen interaction or environmental conditions may contribute to IPD risk. Objectives: To evaluate the short-term associations of influenza activity and environmental exposures with IPD risk in temperate countries and to examine the generalizability of such associations across multiple jurisdictions. Design, Setting, and Participants: This case-crossover analysis of 19 566 individuals with IPD from 1998 to 2011 combined individual-level outcomes of IPD and population-level exposures. Participants lived in 12 jurisdictions in Canada (the province of Alberta and cities of Toronto, Vancouver, and Halifax), Australia (Perth, Sydney, Adelaide, Brisbane, and Melbourne), and the United States (Baltimore, Providence, and Philadelphia). Data were analyzed in 2019. Exposures: Influenza activity, mean temperature, absolute humidity, and UV radiation at delays of 1 to 3 weeks before case occurrence in each jurisdiction. Main Outcomes and Measures: Matched odds ratios (ORs) for IPD associated with changes in exposure variables, estimated using multivariable conditional logistic regression models. Heterogeneity in effects across jurisdictions were evaluated using random-effects meta-analytic models. Results: This study included 19 566 patients: 9629 from Australia (mean [SD] age, 42.8 [30.8] years; 5280 [54.8%] men), 8522 from Canada (only case date reported), and 1415 from the United States (only case date reported). In adjusted models, increased influenza activity was associated with increases in IPD risk 2 weeks later (adjusted OR [aOR] per SD increase, 1.07; 95% CI, 1.01-1.13). Increased humidity was associated with decreased IPD risk 1 week later (aOR per 1 g/m3, 0.98; 95% CI, 0.96-1.00). Other associations were heterogeneous; metaregression suggested that combinations of environmental factors might represent unique local risk signatures. For example, the heterogeneity in effects of UV radiation and humidity at a 2-week lag was partially explained by variation in temperature (UV index: coefficient, 0.0261; 95% CI, 0.0078 to 0.0444; absolute humidity: coefficient, -0.0077; 95% CI, -0.0125 to -0.0030). Conclusions and Relevance: In this study, influenza was associated with increased IPD risk in temperate countries. This association was not explained by coseasonality or case characteristics and appears generalizable. Absolute humidity was associated with decreased IPD risk in the same jurisdictions. The generalizable nature of these associations has important implications for influenza control and advances the understanding of the seasonality of this important disease.
Keywordinvasive pneumococcal disease
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/13466
- Influenza increases invasive meningococcal disease risk in temperate countries.
- Authors: Salomon A, Berry I, Tuite AR, Drews S, Hatchette T, Jamieson F, Johnson C, Kwong J, Lina B, Lojo J, Mosnier A, Ng V, Vanhems P, Fisman DN
- Issue date: 2020 Jan 11
- Evaluation of coseasonality of influenza and invasive pneumococcal disease: results from prospective surveillance.
- Authors: Kuster SP, Tuite AR, Kwong JC, McGeer A, Toronto Invasive Bacterial Diseases Network Investigators., Fisman DN
- Issue date: 2011 Jun
- Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia, Pennsylvania.
- Authors: White AN, Ng V, Spain CV, Johnson CC, Kinlin LM, Fisman DN
- Issue date: 2009 Dec 4
- Multicity study of air pollution and mortality in Latin America (the ESCALA study).
- Authors: Romieu I, Gouveia N, Cifuentes LA, de Leon AP, Junger W, Vera J, Strappa V, Hurtado-Díaz M, Miranda-Soberanis V, Rojas-Bracho L, Carbajal-Arroyo L, Tzintzun-Cervantes G, HEI Health Review Committee.
- Issue date: 2012 Oct
- Occurrence of invasive pneumococcal disease and number of excess cases due to influenza.
- Authors: Grabowska K, Högberg L, Penttinen P, Svensson A, Ekdahl K
- Issue date: 2006 Mar 20