Show simple item record

dc.contributor.authorStaats, Paul N.
dc.contributor.authorSouers, Rhona J.
dc.contributor.authorNunez, Amberly Lindau
dc.contributor.authorLi, Zaibo
dc.contributor.authorKurtycz, Daniel F. I.
dc.contributor.authorGoodrich, Kelly
dc.contributor.authorWitt, Benjamin Lloyd
dc.contributor.authorDavey, Diane Davis
dc.contributor.authorBooth, Christine Noga
dc.date.accessioned2020-07-28T14:29:16Z
dc.date.available2020-07-28T14:29:16Z
dc.date.issued2020-07
dc.identifier.urihttp://hdl.handle.net/10713/13425
dc.description.abstractContext.-Repair is a challenging diagnosis and a significant source of false-positive (FP) interpretations in cervical cytology. No large-scale study of performance of repair in the liquid-based era has been performed. Objective.-To evaluate the performance of repair in the College of American Pathologists Pap Education and Proficiency Testing (PT) programs. Design.-The FP rate for slides classified as repair was evaluated by preparation type, participant type (cytotechnologist, pathologist, or laboratory), and program. The specific misdiagnosis category and individual slide performance were also evaluated. The rate of misclassification of slides as repair by participants for other diagnostic categories in the Pap Education program was assessed. Results.-The overall FP rate was 1700 of 12 715 (13.4%). There was no significant difference by program or preparation type. Within the Education program there was no difference by participant type, but pathologists' FP rate in the PT program (47 of 514, 9.1%) was significantly better than cytotechnologists in the PT program (51 of 380, 13.4%) and pathologists in the Education program (690 of 4900, 14.1%). High-grade squamous intraepithelial lesions/cancers (HSILþ) accounted for 1380 of 1602 FP interpretations (86%) in Education, but 43 of 98 (43.9%) in PT. Most slides had a low rate of misclassification, but a small number were poor performers. False-negative diagnosis of HSILþ as repair was less common, ranging from 0.7% to 1.8%. Conclusions.-Despite initial indications that liquid-based cytology might reduce the rate of misclassification of repair, FP interpretations remain common and are no different by preparation type. Misclassification is most commonly as HSIL or carcinoma, potentially resulting in significant patient harm.en_US
dc.description.urihttps://doi.org/10.5858/arpa.2019-0298-CPen_US
dc.language.isoen_USen_US
dc.publisherCollege of American Pathologistsen_US
dc.relation.ispartofArchives of Pathology and Laboratory Medicineen_US
dc.subject.meshCervix Uteri--cytologyen_us
dc.subject.meshCervix Uteri--pathologyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshPathology, Clinical--educationen_US
dc.titleThe Differential Diagnosis of Reparative Changes and Malignancy: Performance in the College of American Pathologists Pap Education and Proficiency Testing Programsen_US
dc.typeArticleen_US
dc.identifier.doi10.5858/arpa.2019-0298-cp
dc.source.volume144
dc.source.issue7
dc.source.beginpage846
dc.source.endpage852


This item appears in the following Collection(s)

Show simple item record