Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients—Neuroradiological Review Within the MRI-GENIE Study
Author
Drake, MattiasFrid, Petrea
Hansen, Björn M.
Wu, Ona
Giese, Anne-Katrin
Schirmer, Markus D.
Donahue, Kathleen
Cloonan, Lisa
Irie, Robert E.
Bouts, Mark J. R. J.
McIntosh, Elissa C.
Mocking, Steven J. T.
Dalca, Adrian V.
Sridharan, Ramesh
Xu, Huichun
Giralt-Steinhauer, Eva
Holmegaard, Lukas
Jood, Katarina
Roquer, Jaume
Cole, John W.
McArdle, Patrick F.
Broderick, Joseph P.
Jiménez-Conde, Jordi
Jern, Christina
Kissela, Brett M.
Kleindorfer, Dawn O.
Lemmens, Robin
Meschia, James F.
Rundek, Tatjana
Sacco, Ralph L.
Schmidt, Reinhold
Sharma, Pankaj
Slowik, Agnieszka
Thijs, Vincent
Woo, Daniel
Worrall, Bradford B.
Kittner, Steven J.
Mitchell, Braxton D.
Rosand, Jonathan
Golland, Polina
Lindgren, Arne
Rost, Natalia S.
Wassélius, Johan
Date
2020-06-25Journal
Frontiers in NeurologyPublisher
Frontiers Media SAType
Article
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Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work. Methods: The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N = 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics. Results: In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P = 0.013 for χ2 test). Conclusions: This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.Keyword
Magnetic Resonance SpectroscopyMRI-Genetic Interface Exploration (MRI-GENIE)
Neuroimaging
Stroke--genetics
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http://hdl.handle.net/10713/13404ae974a485f413a2113503eed53cd6c53
10.3389/fneur.2020.00577
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/