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dc.contributor.authorKurokawa, C.
dc.contributor.authorLynn, G.E.
dc.contributor.authorPedra, J.H.F.
dc.contributor.authorPal, U.
dc.contributor.authorNarasimhan, S.
dc.contributor.authorFikrig, E.
dc.date.accessioned2020-07-22T20:17:10Z
dc.date.available2020-07-22T20:17:10Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087836964&doi=10.1038%2fs41579-020-0400-5&partnerID=40&md5=b925a5f92f2bff325de764142bed5243
dc.identifier.urihttp://hdl.handle.net/10713/13389
dc.description.abstractBorrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic metabolic functions and has developed complex interactions with ticks to successfully colonize, persist and, at the optimal time, exit the tick. For example, proteins shield spirochaetes from immune factors in the bloodmeal and facilitate the transition between vertebrate and arthropod environments. On infection, B. burgdorferi induces selected tick proteins that modulate the vector gut microbiota towards an environment that favours colonization by the spirochaete. Additionally, the recent sequencing of the Ixodes scapularis genome and characterization of tick immune defence pathways, such as the JAK–STAT, immune deficiency and cross-species interferon-γ pathways, have advanced our understanding of factors that are important for B. burgdorferi persistence in the tick. In this Review, we summarize interactions between B. burgdorferi and I. scapularis during infection, as well as interactions with tick gut and salivary gland proteins important for establishing infection and transmission to the vertebrate host.en_US
dc.description.sponsorshipThis work was supported by grants from the NIH (AI126033 and AI138949) and the Steven and Alexandra Cohen Foundation. E.F. is an investigator with the Howard Hughes Medical Institute. C.K. is supported by an NIH immunohematopathology research training grant (T32HL007974).en_US
dc.description.urihttps://doi.org/10.1038/s41579-020-0400-5en_US
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.ispartofNature Reviews Microbiology
dc.subject.meshBorrelia bergdorferien_US
dc.subject.meshIxodesen_US
dc.subject.meshInsect Vectors--physiologyen_US
dc.titleInteractions between Borrelia burgdorferi and ticksen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41579-020-0400-5
dc.identifier.pmid32651470


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