Date
2020Journal
Nature Reviews MicrobiologyPublisher
Nature ResearchType
Article
Metadata
Show full item recordAbstract
Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic metabolic functions and has developed complex interactions with ticks to successfully colonize, persist and, at the optimal time, exit the tick. For example, proteins shield spirochaetes from immune factors in the bloodmeal and facilitate the transition between vertebrate and arthropod environments. On infection, B. burgdorferi induces selected tick proteins that modulate the vector gut microbiota towards an environment that favours colonization by the spirochaete. Additionally, the recent sequencing of the Ixodes scapularis genome and characterization of tick immune defence pathways, such as the JAK–STAT, immune deficiency and cross-species interferon-γ pathways, have advanced our understanding of factors that are important for B. burgdorferi persistence in the tick. In this Review, we summarize interactions between B. burgdorferi and I. scapularis during infection, as well as interactions with tick gut and salivary gland proteins important for establishing infection and transmission to the vertebrate host.Sponsors
This work was supported by grants from the NIH (AI126033 and AI138949) and the Steven and Alexandra Cohen Foundation. E.F. is an investigator with the Howard Hughes Medical Institute. C.K. is supported by an NIH immunohematopathology research training grant (T32HL007974).Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087836964&doi=10.1038%2fs41579-020-0400-5&partnerID=40&md5=b925a5f92f2bff325de764142bed5243; http://hdl.handle.net/10713/13389ae974a485f413a2113503eed53cd6c53
10.1038/s41579-020-0400-5
Scopus Count
Collections
Related articles
- Differential expression of Ixodes ricinus salivary gland proteins in the presence of the Borrelia burgdorferi sensu lato complex.
- Authors: Cotté V, Sabatier L, Schnell G, Carmi-Leroy A, Rousselle JC, Arsène-Ploetze F, Malandrin L, Sertour N, Namane A, Ferquel E, Choumet V
- Issue date: 2014 Jan 16
- The Lyme disease agent exploits a tick protein to infect the mammalian host.
- Authors: Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E
- Issue date: 2005 Jul 28
- An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borrelia burgdorferi sensu lato from Human Complement.
- Authors: Wagemakers A, Coumou J, Schuijt TJ, Oei A, Nijhof AM, van 't Veer C, van der Poll T, Bins AD, Hovius JW
- Issue date: 2016 Apr
- Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut.
- Authors: Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW
- Issue date: 2016 Mar
- Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete.
- Authors: Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E
- Issue date: 2014 Jan 15