JournalNature Reviews Microbiology
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AbstractBorrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic metabolic functions and has developed complex interactions with ticks to successfully colonize, persist and, at the optimal time, exit the tick. For example, proteins shield spirochaetes from immune factors in the bloodmeal and facilitate the transition between vertebrate and arthropod environments. On infection, B. burgdorferi induces selected tick proteins that modulate the vector gut microbiota towards an environment that favours colonization by the spirochaete. Additionally, the recent sequencing of the Ixodes scapularis genome and characterization of tick immune defence pathways, such as the JAK–STAT, immune deficiency and cross-species interferon-γ pathways, have advanced our understanding of factors that are important for B. burgdorferi persistence in the tick. In this Review, we summarize interactions between B. burgdorferi and I. scapularis during infection, as well as interactions with tick gut and salivary gland proteins important for establishing infection and transmission to the vertebrate host.
SponsorsThis work was supported by grants from the NIH (AI126033 and AI138949) and the Steven and Alexandra Cohen Foundation. E.F. is an investigator with the Howard Hughes Medical Institute. C.K. is supported by an NIH immunohematopathology research training grant (T32HL007974).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087836964&doi=10.1038%2fs41579-020-0400-5&partnerID=40&md5=b925a5f92f2bff325de764142bed5243; http://hdl.handle.net/10713/13389
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- Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut.
- Authors: Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW
- Issue date: 2016 Mar
- Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.
- Authors: Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E
- Issue date: 2017 Aug 4
- Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks.
- Authors: Eisen L
- Issue date: 2018 Mar
- Regulatory protein BBD18 of the lyme disease spirochete: essential role during tick acquisition?
- Authors: Hayes BM, Dulebohn DP, Sarkar A, Tilly K, Bestor A, Ambroggio X, Rosa PA
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