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dc.contributor.authorEley, J.G.
dc.contributor.authorChadha, A.S.
dc.contributor.authorQuini, C.
dc.contributor.authorVichaya, E.G.
dc.contributor.authorZhang, C.
dc.contributor.authorDavis, J.
dc.contributor.authorSahoo, N.
dc.contributor.authorWaddell, J.
dc.contributor.authorLeiser, D.
dc.contributor.authorDilmanian, F.A.
dc.contributor.authorKrishnan, S.
dc.date.accessioned2020-07-22T20:17:07Z
dc.date.available2020-07-22T20:17:07Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087718709&doi=10.1038%2fs41598-020-68015-0&partnerID=40&md5=0fb9939bd675ee815394e914460ee6b6
dc.identifier.urihttp://hdl.handle.net/10713/13367
dc.description.abstractProton minibeams (MBs) comprised of parallel planar beamlets were evaluated for their ability to spare healthy brain compared to proton broad beams (BBs). Juvenile mice were given partial brain irradiation of 10 or 30 Gy integral dose using 100 MeV protons configured either as BBs or arrays of 0.3-mm planar MBs spaced 1.0 mm apart on center. Neurologic toxicity was evaluated during an 8-month surveillance: no overt constitutional or neurologic dysfunction was noted for any study animals. Less acute epilation was observed in MB than BB mice. Persistent chronic inflammation was noted along the entire BB path in BB mice whereas inflammation was confined to just within the MB peak regions in MB mice. The potential neurologic sparing, possibly via reduced volume of chronic inflammation, offers a compelling rationale for clinical advancement of this proton technique. Copyright 2020, The Author(s).en_US
dc.description.sponsorshipUniversity of Texas MD Anderson Cancer Center P30 CA16672; National Institutes of Health, NIH 1R21CA191818en_US
dc.description.urihttps://doi.org/10.1038/s41598-020-68015-0en_US
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reports
dc.subjectproton broad beams (BBs)en_US
dc.subjectproton minibeams (MBs)en_US
dc.subject.meshBrainen_US
dc.subject.meshInflammationen_US
dc.subject.meshProton Therapy--adverse effectsen_US
dc.titlePilot study of neurologic toxicity in mice after proton minibeam therapyen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-020-68015-0
dc.identifier.pmid32647361


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