Immune status, and not HIV infection or exposure, drives the development of the oral microbiota
MetadataShow full item record
AbstractEven with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Saliva samples from 286 child-participants in Nigeria, aged ≤ 6 years, were analyzed using 16S rRNA gene sequencing. Perinatal HIV infection was significantly associated with community composition (HI vs. HUU-p = 0.04; HEU vs. HUU-p = 0.11) however, immune status had stronger impacts on bacterial profiles (p < 0.001). We observed age-stratified associations of perinatal HIV exposure on community composition, with HEU children differing from HUU children in early life but HEU children becoming more similar to HUU children with age. Our findings suggest that, regardless of age, HIV infection or exposure, low CD4 levels persistently alter the oral microbiota during this critical developmental period. Data also indicates that, while HIV infection clearly shapes the developing infant oral microbiome, the effect of perinatal exposure (without infection) appears transient. Copyright 2020, The Author(s).
SponsorsThe research reported in this publication was supported by Fogarty AIDS International Training and Research Program (D43TW01041) and the National Institutes of Health (R01DE025174).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087306150&doi=10.1038%2fs41598-020-67487-4&partnerID=40&md5=c91b00b74f3b2f11346d48c13b4b1c34; http://hdl.handle.net/10713/13293
- Caries experience and oral health related quality of life in a cohort of Ugandan HIV-1 exposed uninfected children compared with a matched cohort of HIV unexposed uninfected children.
- Authors: Birungi N, Fadnes LT, Engebretsen IMS, Lie SA, Tumwine JK, Åstrøm AN, ANRS 12174 and 12341 study groups.
- Issue date: 2020 Mar 30
- Proportions of CD4+, CD8+ and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children.
- Authors: Longwe H, Phiri KS, Mbeye NM, Gondwe T, Jambo KC, Mandala WL
- Issue date: 2015 Aug 28
- Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner.
- Authors: Amenyogbe N, Dimitriu P, Cho P, Ruck C, Fortuno ES 3rd, Cai B, Alimenti A, Côté HCF, Maan EJ, Slogrove AL, Esser M, Marchant A, Goetghebuer T, Shannon CP, Tebbutt SJ, Kollmann TR, Mohn WW, Smolen KK
- Issue date: 2020 Nov 15
- Health and survival of HIV perinatally exposed but uninfected children born to HIV-infected mothers.
- Authors: Desmonde S, Goetghebuer T, Thorne C, Leroy V
- Issue date: 2016 Sep
- Rates of Hospitalization and Infection-Related Hospitalization Among Human Immunodeficiency Virus (HIV)-Exposed Uninfected Children Compared to HIV-Unexposed Uninfected Children in the United States, 2007-2016.
- Authors: Labuda SM, Huo Y, Kacanek D, Patel K, Huybrechts K, Jao J, Smith C, Hernandez-Diaz S, Scott G, Burchett S, Kakkar F, Chadwick EG, Van Dyke RB, Pediatric HIV/AIDS Cohort Study.
- Issue date: 2020 Jul 11