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dc.contributor.authorLiu, J.
dc.contributor.authorTang, W.
dc.contributor.authorGuarnera, M.
dc.date.accessioned2020-07-07T19:59:45Z
dc.date.available2020-07-07T19:59:45Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086923612&doi=10.1016%2fj.cell.2020.05.038&partnerID=40&md5=eccfd312eebd7740b5fee0e369e05962
dc.identifier.urihttp://hdl.handle.net/10713/13243
dc.description.abstractHepatocellular carcinoma (HCC) is an aggressive malignancy with its global incidence and mortality rate continuing to rise, although early detection and surveillance are suboptimal. We performed serological profiling of the viral infection history in 899 individuals from an NCI-UMD case-control study using a synthetic human virome, VirScan. We developed a viral exposure signature and validated the results in a longitudinal cohort with 173 at-risk patients who had long-term follow-up for HCC development. Our viral exposure signature significantly associated with HCC status among at-risk individuals in the validation cohort (area under the curve: 0.91 [95% CI 0.87–0.96] at baseline and 0.98 [95% CI 0.97–1] at diagnosis). The signature identified cancer patients prior to a clinical diagnosis and was superior to alpha-fetoprotein. In summary, we established a viral exposure signature that can predict HCC among at-risk patients prior to a clinical diagnosis, which may be useful in HCC surveillance.en_US
dc.description.sponsorshipThis work was supported in part by grants (ZIA-BC010313, ZIA-BC010876, ZIA BC 010877, and ZIA BC 011870) from the Intramural Research Program of the Center for Cancer Research of the National Cancer Institute and from the NIH DDIR Innovation Award.en_US
dc.description.urihttps://doi.org/10.1016/j.cell.2020.05.038en_US
dc.language.isoen_USen_US
dc.publisherCell Pressen_US
dc.relation.ispartofCell
dc.subjectviral exposure signatureen_US
dc.subjectEarly Detection of Cancer--methodsen_US
dc.subjectCarcinoma, Hepatocellular--diagnosisen_US
dc.titleA Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinomaen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cell.2020.05.038
dc.identifier.pmid32526205


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