A Viral Exposure Signature Defines Early Onset of Hepatocellular Carcinoma
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AbstractHepatocellular carcinoma (HCC) is an aggressive malignancy with its global incidence and mortality rate continuing to rise, although early detection and surveillance are suboptimal. We performed serological profiling of the viral infection history in 899 individuals from an NCI-UMD case-control study using a synthetic human virome, VirScan. We developed a viral exposure signature and validated the results in a longitudinal cohort with 173 at-risk patients who had long-term follow-up for HCC development. Our viral exposure signature significantly associated with HCC status among at-risk individuals in the validation cohort (area under the curve: 0.91 [95% CI 0.87–0.96] at baseline and 0.98 [95% CI 0.97–1] at diagnosis). The signature identified cancer patients prior to a clinical diagnosis and was superior to alpha-fetoprotein. In summary, we established a viral exposure signature that can predict HCC among at-risk patients prior to a clinical diagnosis, which may be useful in HCC surveillance.
SponsorsThis work was supported in part by grants (ZIA-BC010313, ZIA-BC010876, ZIA BC 010877, and ZIA BC 011870) from the Intramural Research Program of the Center for Cancer Research of the National Cancer Institute and from the NIH DDIR Innovation Award.
Keywordviral exposure signature
Early Detection of Cancer--methods
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086923612&doi=10.1016%2fj.cell.2020.05.038&partnerID=40&md5=eccfd312eebd7740b5fee0e369e05962; http://hdl.handle.net/10713/13243