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    A Simulation Study on the Pacing and Driving of the Biological Pacemaker

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    Author
    Zhang, Y.
    Zhang, L.
    Wang, Y.
    Date
    2020
    Journal
    BioMed Research International
    Publisher
    Hindawi Limited
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1155/2020/4803172
    Abstract
    The research on the biological pacemaker has been very active in recent years. And turning nonautomatic ventricular cells into pacemaking cells is believed to hold the key to making a biological pacemaker. In the study, the inward-rectifier K+ current (IK1) is depressed to induce the automaticity of the ventricular myocyte, and then, the effects of the other membrane ion currents on the automaticity are analyzed. It is discovered that the L-type calcium current (ICaL) plays a major part in the rapid depolarization of the action potential (AP). A small enough ICaL would lead to the failure of the automaticity of the ventricular myocyte. Meanwhile, the background sodium current (IbNa), the background calcium current (IbCa), and the Na+/Ca2+ exchanger current (INaCa) contribute significantly to the slow depolarization, indicating that these currents are the main supplementary power of the pacing induced by depressing IK1, while in the 2D simulation, we find that the weak electrical coupling plays a more important role in the driving of a biological pacemaker. Copyright 2020 Yue Zhang et al.
    Keyword
    biological pacemaker
    ventricular myocytes
    Biological Clocks--physiology
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086846418&doi=10.1155%2f2020%2f4803172&partnerID=40&md5=51447976a7a0f4060a655d7b9978fad6; http://hdl.handle.net/10713/13242
    ae974a485f413a2113503eed53cd6c53
    10.1155/2020/4803172
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