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    A systematic review of metabolomic and lipidomic candidates for biomarkers in radiation injury

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    Author
    Vicente, E.
    Vujaskovic, Z.
    Jackson, I.L.
    Date
    2020
    Journal
    Metabolites
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/metabo10060259
    Abstract
    A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and appropriate medical intervention. Extensive progress has been made to develop post-exposure point-of-care biodosimetry assays and to identify biomarkers that may be used in early phase testing to predict the course of the disease. Screening for biomarkers has recently extended to identify specific metabolomic and lipidomic responses to radiation using animal models. The objective of this review was to determine which metabolites or lipids most frequently experienced perturbations postionizing irradiation (IR) in preclinical studies using animal models of acute radiation sickness (ARS) and delayed effects of acute radiation exposure (DEARE). Upon review of approximately 65 manuscripts published in the peer-reviewed literature, the most frequently referenced metabolites showing clear changes in IR induced injury were found to be citrulline, citric acid, creatine, taurine, carnitine, xanthine, creatinine, hypoxanthine, uric acid, and threonine. Each metabolite was evaluated by specific study parameters to determine whether trends were in agreement across several studies. A select few show agreement across variable animal models, IR doses and timepoints, indicating that they may be ubiquitous and appropriate for use in diagnostic or prognostic biomarker panels. Copyright 2020 by the authors. Licensee MDPI, Basel, Switzerland.
    Keyword
    Biomarker
    Ceramide
    Citric acid
    Citrulline
    Creatine
    Diagnostic
    Lipidomic
    Metabolomic
    Radiation
    Uric acid
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087087163&doi=10.3390%2fmetabo10060259&partnerID=40&md5=9cb643da466a22a2faebf7ea4151709d; http://hdl.handle.net/10713/13233
    ae974a485f413a2113503eed53cd6c53
    10.3390/metabo10060259
    Scopus Count
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    UMB Open Access Articles 2020

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