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dc.contributor.authorMannella, C.A.
dc.date.accessioned2020-07-07T19:59:41Z
dc.date.available2020-07-07T19:59:41Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087031113&doi=10.3389%2ffphys.2020.00536&partnerID=40&md5=24753bdec487b5e5e24da27ec8dad500
dc.identifier.urihttp://hdl.handle.net/10713/13231
dc.description.abstractA fundamental first step in the evolution of eukaryotes was infolding of the chemiosmotic membrane of the endosymbiont. This allowed the proto-eukaryote to amplify ATP generation while constraining the volume dedicated to energy production. In mitochondria, folding of the inner membrane has evolved into a highly regulated process that creates specialized compartments (cristae) tuned to optimize function. Internalizing the inner membrane also presents complications in terms of generating the folds and maintaining mitochondrial integrity in response to stresses. This review describes mechanisms that have evolved to regulate inner membrane topology and either preserve or (when appropriate) rupture the outer membrane. Copyright 2020 Mannella.en_US
dc.description.sponsorshipThis article was based on research supported by NIH grants P41RR01219 and U01HLI163.en_US
dc.description.urihttps://doi.org/10.3389/fphys.2020.00536en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Physiology
dc.subjectchemiosmosisen_US
dc.subjectcrista junctionsen_US
dc.subjectcristaeen_US
dc.subjectmembrane remodelingen_US
dc.subjectmembrane topologyen_US
dc.subjectmitochondriaen_US
dc.titleConsequences of Folding the Mitochondrial Inner Membraneen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fphys.2020.00536


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