JournalFrontiers in Physiology
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractA fundamental first step in the evolution of eukaryotes was infolding of the chemiosmotic membrane of the endosymbiont. This allowed the proto-eukaryote to amplify ATP generation while constraining the volume dedicated to energy production. In mitochondria, folding of the inner membrane has evolved into a highly regulated process that creates specialized compartments (cristae) tuned to optimize function. Internalizing the inner membrane also presents complications in terms of generating the folds and maintaining mitochondrial integrity in response to stresses. This review describes mechanisms that have evolved to regulate inner membrane topology and either preserve or (when appropriate) rupture the outer membrane. Copyright 2020 Mannella.
SponsorsThis article was based on research supported by NIH grants P41RR01219 and U01HLI163.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087031113&doi=10.3389%2ffphys.2020.00536&partnerID=40&md5=24753bdec487b5e5e24da27ec8dad500; http://hdl.handle.net/10713/13231