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dc.contributor.authorZheng, Z.
dc.contributor.authorAo, X.
dc.contributor.authorXu, H.H.K.en_US
dc.date.accessioned2020-07-07T19:59:30Z
dc.date.available2020-07-07T19:59:30Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087124426&doi=10.1038%2fs41598-020-67678-z&partnerID=40&md5=f25b1f57e11b13f81c885938373fbb7b
dc.identifier.urihttp://hdl.handle.net/10713/13218
dc.description.abstractTitanium (Ti) has achieved extensive applications due to its excellent biocompatibility and mechanical properties. Plasma can enhance surface hydrophilia of Ti with decreased carbon contamination. The traditional conditions using a single gas plasma was for longer treatment time and more prone to being contaminated. We designed and developed novel and universal apparatus and methods with a special clamping device of non-thermal atmospheric plasma (NTAP) treatment using mixed gas for Ti surface activation. We systematically and quantitatively investigated the effective effects of NTAP-Ti. The surface water contact angle decreased by 100%, the carbon content decreased by 80% and oxygen content increased by 50% in the novel NTAP-Ti surfaces. NTAP treatment accelerated the attachment, spread, proliferation, osteogenic differentiation and mineralization of MC3T3-E1 mouse preosteoblasts in vitro. The percentage of bone-to-implant contact increased by 25-40%, and the osteoclasts and bone resorption were suppressed by 50% in NTAP-Ti in vivo. In conclusion, NTAP-Ti substantially enhanced the physical and biological effects and integration with bone. The novel and universal apparatus and methods with a special clamping device using gas mixtures are promising for implant activation by swiftly and effectively changing the Ti surface to a hydrophilic one to enhance dental and orthopedic applications. Copyright 2020, The Author(s).en_US
dc.description.sponsorshipThis work was financially supported by Research and Develop Program, West China Hospital of Stomatology, Sichuan University (No. LCYJ2019-13), Technology Research and Development Project of Chengdu Science (2019-YF05-01328-SN).en_US
dc.description.urihttps://doi.org/10.1038/s41598-020-67678-zen_US
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.ispartofScientific Reports
dc.subject.meshOsseointegrationen_US
dc.subject.meshTitanium--therapeutic useen_US
dc.titleEffects of novel non-thermal atmospheric plasma treatment of titanium on physical and biological improvements and in vivo osseointegration in ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-020-67678-z


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