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    Effects of novel non-thermal atmospheric plasma treatment of titanium on physical and biological improvements and in vivo osseointegration in rats

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    Author
    Zheng, Z.
    Ao, X.
    Xu, H.H.K.
    Date
    2020
    Journal
    Scientific Reports
    Publisher
    Nature Research
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s41598-020-67678-z
    Abstract
    Titanium (Ti) has achieved extensive applications due to its excellent biocompatibility and mechanical properties. Plasma can enhance surface hydrophilia of Ti with decreased carbon contamination. The traditional conditions using a single gas plasma was for longer treatment time and more prone to being contaminated. We designed and developed novel and universal apparatus and methods with a special clamping device of non-thermal atmospheric plasma (NTAP) treatment using mixed gas for Ti surface activation. We systematically and quantitatively investigated the effective effects of NTAP-Ti. The surface water contact angle decreased by 100%, the carbon content decreased by 80% and oxygen content increased by 50% in the novel NTAP-Ti surfaces. NTAP treatment accelerated the attachment, spread, proliferation, osteogenic differentiation and mineralization of MC3T3-E1 mouse preosteoblasts in vitro. The percentage of bone-to-implant contact increased by 25-40%, and the osteoclasts and bone resorption were suppressed by 50% in NTAP-Ti in vivo. In conclusion, NTAP-Ti substantially enhanced the physical and biological effects and integration with bone. The novel and universal apparatus and methods with a special clamping device using gas mixtures are promising for implant activation by swiftly and effectively changing the Ti surface to a hydrophilic one to enhance dental and orthopedic applications. Copyright 2020, The Author(s).
    Sponsors
    This work was financially supported by Research and Develop Program, West China Hospital of Stomatology, Sichuan University (No. LCYJ2019-13), Technology Research and Development Project of Chengdu Science (2019-YF05-01328-SN).
    Keyword
    Osseointegration
    Titanium--therapeutic use
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087124426&doi=10.1038%2fs41598-020-67678-z&partnerID=40&md5=f25b1f57e11b13f81c885938373fbb7b; http://hdl.handle.net/10713/13218
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-020-67678-z
    Scopus Count
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