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dc.contributor.authorHu, X.
dc.contributor.authorChen, H.
dc.contributor.authorXu, H.
dc.date.accessioned2020-06-30T18:46:30Z
dc.date.available2020-06-30T18:46:30Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086686282&doi=10.7150%2fijbs.45467&partnerID=40&md5=7d5fc14c9cf6b58d9c047c6b8bbdb63c
dc.identifier.urihttp://hdl.handle.net/10713/13199
dc.description.abstractCentral nervous system (CNS) trauma, including traumatic brain injury (TBI) and spinal cord injury (SCI), remains a leading cause for morbidity and mortality worldwide. Past research has shown that cell death plays a critical role in the pathophysiology of CNS injuries. More recently, pyroptosis has been identified as a form of programmed inflammatory cell death, and it is a unique form of cell death in various aspects. Mechanistically, pyroptosis can be categorized into canonical (mediated by caspase-1) and non-canonical (mediated by caspase-4/5/11). In canonical pyroptosis, Nod-like receptors (NLRs) inflammasomes play a critical role, and their activation promotes the maturation and secretion of the inflammatory cytokines interleukin-1?/18 (IL-1?/18), cleavage of gasdermin D (GSDMD), and ultimately pyroptotic cell death. Despite a plethora of new knowledge regarding pyroptosis, detailed understanding of how pyroptosis is involved in CNS injuries and possible ways to improve clinical outcomes following CNS injuries remain elusive. This review discusses the current knowledge on how pyroptosis is involved in CNS injuries, focusing on new discoveries regarding how pyroptosis activation occurs, differences between CNS cell types following injury, time-course of inflammatory responses, and key regulatory steps of pyroptosis. In addition, we highlight various investigational agents that are capable of regulating key steps in pyroptotic cell death, and we discuss how these agents may be used as therapies to improve outcomes following CNS trauma. CopyrightThe author(s).en_US
dc.description.urihttps://doi.org/10.7150/ijbs.45467en_US
dc.language.isoen_USen_US
dc.publisherIvyspring International Publisheren_US
dc.relation.ispartofInternational journal of biological sciences
dc.subjectCell deathen_US
dc.subjectInflammasomesen_US
dc.subjectPyroptosisen_US
dc.subjectSpinal cord injuryen_US
dc.subjectTraumatic brain injuryen_US
dc.titleRole of Pyroptosis in Traumatic Brain and Spinal Cord Injuriesen_US
dc.typeArticleen_US
dc.identifier.doi10.7150/ijbs.45467
dc.identifier.pmid32549752


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