JournalInternational journal of biological sciences
PublisherIvyspring International Publisher
MetadataShow full item record
AbstractCentral nervous system (CNS) trauma, including traumatic brain injury (TBI) and spinal cord injury (SCI), remains a leading cause for morbidity and mortality worldwide. Past research has shown that cell death plays a critical role in the pathophysiology of CNS injuries. More recently, pyroptosis has been identified as a form of programmed inflammatory cell death, and it is a unique form of cell death in various aspects. Mechanistically, pyroptosis can be categorized into canonical (mediated by caspase-1) and non-canonical (mediated by caspase-4/5/11). In canonical pyroptosis, Nod-like receptors (NLRs) inflammasomes play a critical role, and their activation promotes the maturation and secretion of the inflammatory cytokines interleukin-1?/18 (IL-1?/18), cleavage of gasdermin D (GSDMD), and ultimately pyroptotic cell death. Despite a plethora of new knowledge regarding pyroptosis, detailed understanding of how pyroptosis is involved in CNS injuries and possible ways to improve clinical outcomes following CNS injuries remain elusive. This review discusses the current knowledge on how pyroptosis is involved in CNS injuries, focusing on new discoveries regarding how pyroptosis activation occurs, differences between CNS cell types following injury, time-course of inflammatory responses, and key regulatory steps of pyroptosis. In addition, we highlight various investigational agents that are capable of regulating key steps in pyroptotic cell death, and we discuss how these agents may be used as therapies to improve outcomes following CNS trauma. CopyrightThe author(s).
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086686282&doi=10.7150%2fijbs.45467&partnerID=40&md5=7d5fc14c9cf6b58d9c047c6b8bbdb63c; http://hdl.handle.net/10713/13199
- The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
- Authors: Ge X, Li W, Huang S, Yin Z, Xu X, Chen F, Kong X, Wang H, Zhang J, Lei P
- Issue date: 2018 Oct 15
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
- Authors: He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J
- Issue date: 2015 Dec
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
- Authors: Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F
- Issue date: 2015 Oct 29
- Inflammasome: Its role in traumatic brain and spinal cord injury.
- Authors: Mortezaee K, Khanlarkhani N, Beyer C, Zendedel A
- Issue date: 2018 Jul
- The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury.
- Authors: Lee SW, de Rivero Vaccari JP, Truettner JS, Dietrich WD, Keane RW
- Issue date: 2019 Feb 8