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    Polyelectrolyte in Electric Field: Disparate Conformational Behavior along an Aminopolysaccharide Chain

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    Author
    Mahinthichaichan, P.
    Tsai, C.-C.
    Shen, J.
    Date
    2020
    Journal
    ACS Omega
    Publisher
    American Chemical Society
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1021/acsomega.0c00164
    Abstract
    Electrical signals are increasingly used in fabrication of hydrogels (e.g., based on aminopolysaccharide chitosan) to guide the emergence of complex and anisotropic structure; however, how an imposed electric field affects the polymer chain conformation and orientation during the self-assembly process is not understood. Here, we applied nonequilibrium all-atom molecular dynamics simulations to explore the response of a charged chitosan chain comprising 5- or 20-monomer units to a constant uniform electric field in water and salt solution. While no conformational or orientational response was observed for the polyelectrolyte (PE) chains under the small electric fields within the simulation time, a field strength of 400 mV/nm induced significant changes. In water, a 5-mer chain is found to be slightly bent and oriented parallel to the field; however, surprisingly, a 20-mer chain displays candy-cane-like conformations whereby one half of the chain is collapsed and flexible, while the other half of the chain is stretched along the electric field. In salt solution, the disparity remains between the two halves of the 20-mer chain, although the backbone is extremely flexible with multiple bent regions and non-native conformations occur near the chain center in one of the three trajectories. The disparate conformational response along the polyelectrolyte chain may be attributed to the balancing forces between chain dynamics, electric polarization, counterion binding, and hydrodynamic pressure as well as friction. These findings reconcile existing experiments and theoretical studies and represent an important step toward understanding the complex roles of electric field and salt in controlling the structure and properties of soft matter.
    Sponsors
    National Science Foundation, NSF: CBET1932963, CBET1435957
    Keyword
    electrochemically based biofabrication
    Hydrogels
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086674779&doi=10.1021%2facsomega.0c00164&partnerID=40&md5=72025482b4c081ce5c0c8b396a443316; http://hdl.handle.net/10713/13195
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsomega.0c00164
    Scopus Count
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    UMB Open Access Articles 2020

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