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dc.contributor.authorHalperin, Kuhns, V.L.
dc.contributor.authorWoodward, O.M.
dc.date.accessioned2020-06-30T18:46:26Z
dc.date.available2020-06-30T18:46:26Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086754027&doi=10.3390%2fijms21124269&partnerID=40&md5=dd09c7345fabdc282ae1bc29a8383207
dc.identifier.urihttp://hdl.handle.net/10713/13184
dc.description.abstractHyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also increases the incidence of many other conditions including renal disease, cardiovascular disease, and metabolic syndrome. As we gain mechanistic insight into how urate contributes to human disease, a clear sex difference has emerged in the physiological regulation of urate homeostasis. This review summarizes our current understanding of urate as a disease risk factor and how being of the female sex appears protective. Further, we review the mechanisms of renal handling of urate and the significant contributions from powerful genome-wide association studies of serum urate. We also explore the role of sex in the regulation of specific renal urate transporters and the power of new animal models of hyperuricemia to inform on the role of sex and hyperuricemia in disease pathogenesis. Finally, we advocate the use of sex differences in urate handling as a potent tool in gaining a further understanding of physiological regulation of urate homeostasis and for presenting new avenues for treating the constellation of urate related pathologies.en_US
dc.description.urihttps://doi.org/10.3390/ijms21124269en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational journal of molecular sciences
dc.subjectABCG2en_US
dc.subjectgouten_US
dc.subjectserum urateen_US
dc.subjectsex differencesen_US
dc.subjectSLC2A9en_US
dc.subjectURAT1en_US
dc.subjecturic aciden_US
dc.titleSex Differences in Urate Handlingen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms21124269
dc.identifier.pmid32560040


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