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    Plasma soluble P-selectin correlates with triglycerides and nitrite in overweight/obese patients with schizophrenia

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    Author
    Bourassa, K.A.
    Postolache, T.T.
    Dagdag, A.
    Date
    2020
    Journal
    Pteridines
    Publisher
    De Gruyter
    Type
    Article
    
    Metadata
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    See at
    https://doi.org/10.1515/pteridines-2020-0012
    Abstract
    Background: Soluble P-selectin (sP-selectin) is associated with risk factors for cardiovascular disease (CVD) but this association has not been evaluated in patients with schizophrenia. This study primarily evaluated the association of sP-selectin with plasma lipids and nitrite (NO2-) respectively in overweight/obese adults with schizophrenia. Methods: One-hundred and six patients with schizophrenia (mean age 32.9 years; 71.60% male) were recruited from a psychiatric hospital. Participants completed a structured interview and provided a fasting blood sample. Body mass index (BMI) was used to divide the sample into normal weight and overweight/obese groups. Pearson's and partial correlation coefficients (controlling for age, sex, race, education, and inflammation) were calculated to examine the association of sP-selectin with plasma lipids, and NO2- in the overweight/obese patients (primary analysis), as well as in the normal weight patients and the total sample (exploratory analyses). Results: After controlling for potential confounders, sP-selectin positively correlated with triglycerides (r = 0.38, p = 0.01) and NO2- (r = 0.40, p < 0.01) in the overweight/ obese group only. Conclusions: Future longitudinal studies should evaluate the utility of sP-selectin as a biomarker of CVD in overweight/obese adults with schizophrenia (for example, by relating sP-selectin to incidence of cardiovascular events). Copyright 2020 Katelynn A. Bourassa et al.
    Keyword
    atherosclerosis
    nitrite
    overweight/obesity
    P-selectin
    schizophrenia
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086263027&doi=10.1515%2fpteridines-2020-0012&partnerID=40&md5=b14b045c81cae002efac426e4f5e831c; http://hdl.handle.net/10713/13144
    ae974a485f413a2113503eed53cd6c53
    10.1515/pteridines-2020-0012
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