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    Genetically modified mesenchymal stem cells: The next generation of stem cell-based therapy for TBI

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    Author
    Shahror, R.A.
    Wu, C.-C.
    Chiang, Y.-H.
    Date
    2020
    Journal
    International Journal of Molecular Sciences
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/ijms21114051
    Abstract
    Mesenchymal stem cells (MSCs) are emerging as an attractive approach for restorative medicine in central nervous system (CNS) diseases and injuries, such as traumatic brain injury (TBI), due to their relatively easy derivation and therapeutic effect following transplantation. However, the long-term survival of the grafted cells and therapeutic efficacy need improvement. Here, we review the recent application of MSCs in TBI treatment in preclinical models. We discuss the genetic modification approaches designed to enhance the therapeutic potency of MSCs for TBI treatment by improving their survival after transplantation, enhancing their homing abilities and overexpressing neuroprotective and neuroregenerative factors. We highlight the latest preclinical studies that have used genetically modified MSCs for TBI treatment. The recent developments in MSCs' biology and potential TBI therapeutic targets may sufficiently improve the genetic modification strategies for MSCs, potentially bringing effective MSC-based therapies for TBI treatment in humans. Copyright 2020 by the authors.
    Keyword
    Cell therapy
    Gene therapy
    Genetic modification
    Mesenchymal stem cells
    Neurogenesis
    Traumatic brain injury
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086167484&doi=10.3390%2fijms21114051&partnerID=40&md5=df3b63a67dcaaa4321bb0fbf6be95c1e; http://hdl.handle.net/10713/13089
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms21114051
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