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dc.contributor.authorNeerukonda, S.N.
dc.contributor.authorKatneni, U.
dc.date.accessioned2020-06-16T19:54:23Z
dc.date.available2020-06-16T19:54:23Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086041727&doi=10.3390%2fpathogens9060426&partnerID=40&md5=f3e50cb56a85acb03c6a17e1ebea5872
dc.identifier.urihttp://hdl.handle.net/10713/13088
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials. Copyright 2020 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/pathogens9060426en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPathogens
dc.subjectAnimal modelsen_US
dc.subjectAntiviralsen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.titleA review on sars-cov-2 virology, pathophysiology, animal models, and anti-viral interventionsen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/pathogens9060426


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