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dc.contributor.authorPratt, S.J.P.
dc.contributor.authorLee, R.M.
dc.contributor.authorMartin, S.S.
dc.date.accessioned2020-06-16T19:54:22Z
dc.date.available2020-06-16T19:54:22Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086132650&doi=10.3390%2fcancers12061452&partnerID=40&md5=62fc225d93f924d28a15100b9bab4f0c
dc.identifier.urihttp://hdl.handle.net/10713/13087
dc.description.abstractMechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells. Copyright 2020 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/cancers12061452en_US
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofCancers
dc.subjectBreast canceren_US
dc.subjectInterstitial fluid pressureen_US
dc.subjectMechanobiologyen_US
dc.subjectMechanoresponsivenessen_US
dc.subjectMechanosensationen_US
dc.subjectMechanotransductionen_US
dc.subjectSolid stressen_US
dc.subjectStiffnessen_US
dc.titleThe mechanical microenvironment in breast canceren_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cancers12061452


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