Abstract
Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells. Copyright 2020 by the authors.Keyword
Breast cancerInterstitial fluid pressure
Mechanobiology
Mechanoresponsiveness
Mechanosensation
Mechanotransduction
Solid stress
Stiffness
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086132650&doi=10.3390%2fcancers12061452&partnerID=40&md5=62fc225d93f924d28a15100b9bab4f0c; http://hdl.handle.net/10713/13087ae974a485f413a2113503eed53cd6c53
10.3390/cancers12061452