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dc.contributor.authorLipford, Erika
dc.date.accessioned2020-06-15T14:23:02Z
dc.date.available2020-06-15T14:23:02Z
dc.date.issued2020en_us
dc.identifier.urihttp://hdl.handle.net/10713/13070
dc.description2020
dc.descriptionMolecular Medicine
dc.descriptionUniversity of Maryland, Baltimore
dc.descriptionM.S.
dc.description.abstractHearing loss is the most common sensory impairment, affecting hundreds of millions of people worldwide. Although both men and women are impacted by hearing loss, the incidence rate differs between the two sexes, with the prevalence of bilateral high-frequency hearing loss reported to be 2.7 times higher in males. Recent studies have implicated estrogen as having a protective effect against hearing loss in females. While the localization of the estrogen receptors within the cochlea is known, the roles of estrogen-related receptors in auditory function require further investigation. The aim of this study is to elucidate the localization of estrogen receptors 1 and 2 and estrogen-related receptors α, β, and γ within the inner ear of adult mice using RNAscope. Our results give insight into the molecular mechanism through which estrogen receptors and estrogen-related receptors may grant protection against hearing loss and contribute to the functionality of the inner ear.
dc.subjectestrogen-related receptorsen_us
dc.subject.meshEar, Inner--physiologyen_us
dc.subject.meshHearing Lossen_us
dc.subject.meshReceptors, Estrogenen_us
dc.titleElucidating the Localization of Estrogen and Estrogen-related Receptors in the Inner Earen_US
dc.typedissertationen_US
dc.date.updated2020-06-04T16:03:58Z
dc.language.rfc3066en
dc.contributor.advisorHertzano, Ronna P.
refterms.dateFOA2020-06-15T14:23:04Z


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