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    Elucidating the Localization of Estrogen and Estrogen-related Receptors in the Inner Ear

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    Author
    Lipford, Erika cc
    Advisor
    Hertzano, Ronna P.
    Date
    2020
    Type
    dissertation
    
    Metadata
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    Abstract
    Hearing loss is the most common sensory impairment, affecting hundreds of millions of people worldwide. Although both men and women are impacted by hearing loss, the incidence rate differs between the two sexes, with the prevalence of bilateral high-frequency hearing loss reported to be 2.7 times higher in males. Recent studies have implicated estrogen as having a protective effect against hearing loss in females. While the localization of the estrogen receptors within the cochlea is known, the roles of estrogen-related receptors in auditory function require further investigation. The aim of this study is to elucidate the localization of estrogen receptors 1 and 2 and estrogen-related receptors α, β, and γ within the inner ear of adult mice using RNAscope. Our results give insight into the molecular mechanism through which estrogen receptors and estrogen-related receptors may grant protection against hearing loss and contribute to the functionality of the inner ear.
    Description
    2020
    Molecular Medicine
    University of Maryland, Baltimore
    M.S.
    Keyword
    estrogen-related receptors
    Ear, Inner--physiology
    Hearing Loss
    Receptors, Estrogen
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13070
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    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

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