• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    The Effect of ZSCAN4 on Telomere Chromatin Remodeling

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Lin_umaryland_0373N_11159.pdf
    Size:
    1.354Mb
    Format:
    PDF
    Download
    Author
    Lin, Phyo Nay cc
    Advisor
    Zalzman, Michal
    Date
    2020
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Telomeres are repetitive sequences at the ends of chromosomes that protect the coding regions of DNA. Telomeres shorten with every cell division and therefore operate as a biological clock. Thus, factors regulating telomeric chromatin impact cell replicative lifespan, tumor formation and growth. The murine Zinc Finger and SCAN Domain Containing 4 (mZscan4) promotes telomere homeostasis and genomic stability in mouse embryonic stem cells (mESCs). A transient expression of mZscan4 was shown to correlate with chromatin de-repression in mESCs. However, the function of human ZSCAN4 in its contribution to the epigenetic landscape changes at telomeric chromatin remains to be determined. In this study, we defined the effect of ZSCAN4 on histone 3 and 4 hyperacetylation at the telomere region which is associated with telomere extension. Understanding the mechanism by which ZSCAN4 affects the telomeric chromatin is important for designing new therapeutic approaches to target cancer cell replicative lifespan.
    Description
    2020
    Cellular & Molecular Biomedical Sciences
    University of Maryland, Baltimore
    M.S.
    Keyword
    epigenetic modifications
    replicative lifespan
    telomere chromatin
    ZSCAN4
    Cancer
    Chromatin
    Telomere
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/13069
    Collections
    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.