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dc.contributor.authorJenne, Carleigh
dc.date.accessioned2020-06-11T15:53:51Z
dc.date.available2020-06-11T15:53:51Z
dc.date.issued2020en_us
dc.identifier.urihttp://hdl.handle.net/10713/13029
dc.description2020
dc.descriptionMolecular Medicine
dc.descriptionUniversity of Maryland, Baltimore
dc.descriptionM.S.
dc.description.abstractChronic pain is the most common cause of disability. Progress in research to alleviate pain is hampered by the fact that metrics for studying pain in animal models are controversial. Rodents highly value social interactions, preferring them even over drugs of abuse or other hedonic rewards. Here, I tested the hypothesis that pain will reduce preference for social interaction, thereby offering a novel tool to quantify pain behaviors. After training rats to self-administer social interaction, I found that acute pain causes devaluation of social interaction. This devaluation was specific to social interaction, because after training rats to self-administer food, acute pain elicited no change in valuation for food self-administration. My findings display the importance of social interaction in pain behaviors, and suggest a novel metric for pain studies.
dc.subjectsocial interactionen_us
dc.subject.meshBehavioren_us
dc.subject.meshChronic Painen_us
dc.subject.meshInterpersonal Relationsen_us
dc.titleSocial Interaction and Painen_US
dc.typedissertationen_US
dc.date.updated2020-06-04T16:03:53Z
dc.language.rfc3066en
dc.contributor.advisorKeller, Asaf
refterms.dateFOA2020-06-11T15:53:53Z


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