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dc.contributor.authorTahmasian, M.
dc.contributor.authorSamea, F.
dc.contributor.authorKochunov, P.
dc.date.accessioned2020-06-08T20:20:58Z
dc.date.available2020-06-08T20:20:58Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85083189889&doi=10.1038%2fs42003-020-0892-6&partnerID=40&md5=d0c3fd78e101ba0a081bdd0d2f39a513
dc.identifier.urihttp://hdl.handle.net/10713/12979
dc.descriptionCorrection to: Communications Biology https://doi.org/10.1038/s42003-020-0892-6. Accessible at http://doi.org/10.1038/s42003-020-1017-y. In the original published version of the article, the Methods section entitled “Statistics and reproducibility” incorrectly stated that the coefficient of relationship between individuals in the HCP sample was computed using the KING method. However, the coefficient of relationship was computed using self-reported twin status data. The error has been corrected in the HTML and PDF versions of the paper.
dc.description.abstractHumans need about seven to nine hours of sleep per night. Sleep habits are heritable, associated with brain function and structure, and intrinsically related to well-being, mental, and physical health. However, the biological basis of the interplay of sleep and health is incompletely understood. Here we show, by combining neuroimaging and behavioral genetic approaches in two independent large-scale datasets (HCP (n = 1106), age range: 22-37, eNKI (n = 783), age range: 12-85), that sleep, mental, and physical health have a shared neurobiological basis in grey matter anatomy; and that these relationships are driven by shared genetic factors. Though local associations between sleep and cortical thickness were inconsistent across samples, we identified two robust latent components, highlighting the multivariate interdigitation of sleep, intelligence, BMI, depression, and macroscale cortical structure. Our observations provide a system-level perspective on the interrelation of sleep, mental, and physical conditions, anchored in grey-matter neuroanatomy. Copyright 2020, The Author(s).en_US
dc.description.sponsorshipNational Research Foundation S10OD023696, R01EB015611; National Research Foundation Singapore; NIH Blueprint for Neuroscience Research National Institutes of Health, NIH Brain Research Foundation, BRF 1U54MH091657 New York State Office of Mental Health, OMH Stavros Niarchos Foundation, SNF Center for Advanced Brain Imaging, CABI University of Minnesota, UM National Institute of Mental Health, NIMH: R01-MH074457 CAB International, CABI Deutsche Forschungsgemeinschaft, DFG: EI 816/21-1 McDonnell Center for Systems Neuroscience 785907en_US
dc.description.urihttp://doi.org/10.1038/s42003-020-0892-6en_US
dc.description.urihttp://doi.org/10.1038/s42003-020-1017-y
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.ispartofCommunications Biology
dc.subject.meshGrey Matteren_US
dc.subject.meshHealthen_US
dc.subject.meshSleep
dc.titleThe interrelation of sleep and mental and physical health is anchored in grey-matter neuroanatomy and under genetic controlen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s42003-020-0892-6
dc.identifier.pmid32273564


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