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dc.contributor.authorSmith, E.C.
dc.contributor.authorLimbach, K.J.
dc.contributor.authorSacci, J.B., Jr.en_US
dc.date.accessioned2020-06-01T18:26:15Z
dc.date.available2020-06-01T18:26:15Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084802209&doi=10.1371%2fjournal.pone.0232234&partnerID=40&md5=35a3c89f45401b13916e4bc63d00e004
dc.identifier.urihttp://hdl.handle.net/10713/12912
dc.description.abstractOnly a small fraction of the antigens expressed by malaria parasites have been evaluated as vaccine candidates. A successful malaria subunit vaccine will likely require multiple antigenic targets to achieve broad protection with high protective efficacy. Here we describe protective efficacy of a novel antigen, Plasmodium yoelii (Py) E140 (PyE140), evaluated against P. yoelii challenge of mice. Vaccines targeting PyE140 reproducibly induced up to 100% sterile protection in both inbred and outbred murine challenge models. Although PyE140 immunization induced high frequency and multifunctional CD8+ T cell responses, as well as CD4+ T cell responses, protection was mediated by PyE140 antibodies acting against blood stage parasites. Protection in mice was long-lasting with up to 100% sterile protection at twelve weeks post-immunization and durable high titer anti-PyE140 antibodies. The E140 antigen is expressed in all Plasmodium species, is highly conserved in both P. falciparum lab-adapted strains and endemic circulating parasites, and is thus a promising lead vaccine candidate for future evaluation against human malaria parasite species. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.en_US
dc.description.sponsorshipUnited States Agency for International Development - USAID, Naval Medical Research Center - NMRC: N6264518C4003, Henry M. Jackson Foundation - HJF, U.S. Department of Defense - DOD, University of Maryland - UMD, Naval Medical Research Center - NMRC: AID-GH-T-17-00002, Walter Reed Army Institute of Research - WRAIR.en_US
dc.description.urihttps://doi.org/10.1371/journal.pone.0232234en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS ONE
dc.subjectPlasmodium yoelii E140en_US
dc.subjectsterile protectionen_US
dc.subjectPyE140 antibodiesen_US
dc.subject.meshMalaria Vaccinesen_US
dc.subject.meshAntigensen_US
dc.subject.meshMiceen_US
dc.titleNovel malaria antigen Plasmodium yoelii E140 induces antibody-mediated sterile protection in mice against malaria challengeen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0232234


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