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    Colorectal cancer and probiotics: Are bugs really drugs?

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    Author
    Lamichhane, P.
    Maiolini, M.
    Lamichhane, N.
    Date
    2020
    Journal
    Cancers
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cancers12051162
    Abstract
    Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person's risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment. Copyright 2020 by the authors.
    Keyword
    Bacteria
    Chemoprevention
    Colorectal cancer
    Gut microflora
    Probiotics
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085054863&doi=10.3390%2fcancers12051162&partnerID=40&md5=f6c1c839906bb18f97f7b57824aa8369; http://hdl.handle.net/10713/12910
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers12051162
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