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    Defensins: A Double-Edged Sword in Host Immunity

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    Author
    Xu, D.
    Lu, W.
    Date
    2020
    Journal
    Frontiers in Immunology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2020.00764
    Abstract
    Defensins are a major family of host defense peptides expressed predominantly in neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted immunomodulatory functions have been extensively studied, cementing their role in innate immunity as a core host-protective component against bacterial, viral and fungal infections. More recent studies, however, paint defensins in a bad light such that they are "alleged" to promote viral and bacterial infections in certain biological settings. This mini review summarizes the latest findings on the potential pathogenic properties of defensins against the backdrop of their protective roles in antiviral and antibacterial immunity. Further, a succinct description of both tumor-proliferative and -suppressive activities of defensins is also given to highlight their functional and mechanistic complexity in antitumor immunity. We posit that given an enabling environment defensins, widely heralded as the "Swiss army knife," can function as a "double-edged sword" in host immunity. Copyright 2020 Xu and Lu.
    Sponsors
    National Natural Science Foundation of China, NSFC 31770146
    Keyword
    antimicrobial peptide
    defensin
    host defense peptide
    host-pathogen interaction
    innate immunity
    Shigella
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085130444&doi=10.3389%2ffimmu.2020.00764&partnerID=40&md5=50d18677b8373e530cadbb5353c8b6c2; http://hdl.handle.net/10713/12905
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2020.00764
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