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dc.contributor.authorKosmac, K.
dc.contributor.authorGonzalez-Freire, M.
dc.contributor.authorGuralnik, J.M.
dc.date.accessioned2020-06-01T18:26:12Z
dc.date.available2020-06-01T18:26:12Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084943568&doi=10.1161%2fJAHA.118.015929&partnerID=40&md5=8063352e2eae22c5ae52ccce5135271b
dc.identifier.urihttp://hdl.handle.net/10713/12901
dc.description.abstractBackground Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility loss. Preliminary evidence suggests PAD damages skeletal muscle, resulting in muscle impairments that contribute to functional decline. We sought to determine whether PAD is associated with an altered macrophage profile in gastrocnemius muscles and whether muscle macrophage populations are associated with impaired muscle phenotype and walking performance in patients with PAD. Methods and Results Macrophages, satellite cells, and extracellular matrix in gastrocnemius muscles from 25 patients with PAD and 7 patients without PAD were quantified using immunohistochemistry. Among patients with PAD, both the absolute number and percentage of cluster of differentiation (CD) 11b+CD206+ M2-like macrophages positively correlated to satellite cell number (r=0.461 [P=0.023] and r=0.416 [P=0.042], respectively) but not capillary density or extracellular matrix. The number of CD11b+CD206- macrophages negatively correlated to 4-meter walk tests at normal (r=-0.447, P=0.036) and fast pace (r=-0.510, P=0.014). Extracellular matrix occupied more muscle area in PAD compared with non-PAD (8.72±2.19% versus 5.30±1.03%, P<0.001) and positively correlated with capillary density (r=0.656, P<0.001). Conclusions Among people with PAD, higher CD206+ M2-like macrophage abundance was associated with greater satellite cell numbers and muscle fiber size. Lower CD206- macrophage abundance was associated with better walking performance. Further study is needed to determine whether CD206+ macrophages are associated with ongoing reparative processes enabling skeletal muscle adaptation to damage with PAD. Registration URL: https://www.clini?caltr?ials.gov; Unique identifiers: NCT00693940, NCT01408901, NCT0224660.en_US
dc.description.urihttps://doi.org/10.1161/JAHA.118.015929en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of the American Heart Association
dc.subjectmacrophageen_US
dc.subjectperipheral artery diseaseen_US
dc.subjectskeletal muscleen_US
dc.subjectwalking performanceen_US
dc.titleCorrelations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1161/JAHA.118.015929
dc.identifier.pmid32390569


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