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dc.contributor.authorFoppiano, Palacios, C.
dc.contributor.authorSaleeb, P.G.
dc.date.accessioned2020-06-01T18:26:12Z
dc.date.available2020-06-01T18:26:12Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084840060&doi=10.1016%2fj.jctube.2020.100164&partnerID=40&md5=246ce89ca5d749b1bc52fb4b413fa28a
dc.identifier.urihttp://hdl.handle.net/10713/12899
dc.description.abstractTuberculosis (TB) continues to pose a significant public health problem. Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary TB. TBM carries a high mortality rate, including for those receiving treatment for TB. Diagnosis of TBM is difficult for clinicians as it can clinically present similarly to other forms of meningitis. The difficulty in diagnosis often leads to a delay in treatment and subsequent mortality. Those who survive are left with long-term sequelae leading to lifelong disability. The microbiologic diagnosis of TBM requires the isolation of Mycobacterium tuberculosis from the cerebrospinal fluid (CSF) of an infected patient. The diagnosis of tuberculous meningitis continues to be challenging for clinicians. Unfortunately, many cases of TBM cannot be confirmed based on clinical and imaging findings as the clinical findings are nonspecific, while laboratory techniques are largely insensitive or slow. Until recently, the lack of accessible and timely tests has contributed to a delay in diagnosis and subsequent morbidity and mortality for many patients, particularly those in resourcelimited settings. The availability of Xpert Ultra and point-of-care lipoarabinomannan (LAM) testing could represent a new era of prompt diagnosis and early treatment of tuberculous meningitis. However, clinicians must be cautious when ruling out TBM with Xpert Ultra due to its low negative predictive value. Due to the limitations of current diagnostics, clinicians should utilize a combination of diagnostic modalities in order to prevent morbidity in patients with TBM. Copyright 2020 The Author(s)en_US
dc.description.urihttps://doi.org/10.1016/j.jctube.2020.100164en_US
dc.language.isoen_USen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofJournal of Clinical Tuberculosis and Other Mycobacterial Diseases
dc.subjectCNSen_US
dc.subjectDiagnosisen_US
dc.subjectDiagnosticsen_US
dc.subjectMeningitisen_US
dc.subjectTuberculomaen_US
dc.subjectTuberculosisen_US
dc.titleChallenges in the diagnosis of tuberculous meningitisen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jctube.2020.100164


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