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dc.contributor.authorJin, H.
dc.contributor.authorLi, G.
dc.contributor.authorZhao, R.Y.
dc.date.accessioned2020-05-28T18:41:22Z
dc.date.available2020-05-28T18:41:22Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084787174&doi=10.1126%2fsciadv.aba3418&partnerID=40&md5=dc711798b23298b617ebc81e6b69171c
dc.identifier.urihttp://hdl.handle.net/10713/12888
dc.description.abstractMany animal viral proteins, e.g., Vpr of HIV-1, disrupt host mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. However, it is unknown whether plant viruses may use this mechanism in their pathogenesis. Here, we report that the 17K protein, encoded by barley yellow dwarf viruses and related poleroviruses, delays G2/M transition and disrupts mitosis in both host (barley) and nonhost (fission yeast, Arabidopsis thaliana, and tobacco) cells through interrupting the function of Wee1-Cdc25-CDKA/Cdc2 via direct protein-protein interactions and alteration of CDKA/Cdc2 phosphorylation. When ectopically expressed, 17K disrupts the mitosis of cultured human cells, and HIV-1 Vpr inhibits plant cell growth. Furthermore, 17K and Vpr share similar secondary structural feature and common amino acid residues required for interacting with plant CDKA. Thus, our work reveals a distinct class of mitosis regulators that are conserved between plant and animal viruses and play active roles in viral pathogenesis. Copyright 2020 The Authors.en_US
dc.description.urihttps://doi.org/10.1126/sciadv.aba3418en_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.ispartofScience advances
dc.subjectmitotic entry switch Wee1-Cdc25-Cdk1en_US
dc.subject.meshViral Proteinsen_US
dc.subject.meshMitosisen_US
dc.titleA distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1en_US
dc.typeArticleen_US
dc.identifier.doi10.1126/sciadv.aba3418
dc.identifier.pmid32426509


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