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dc.contributor.authorNing, X.
dc.contributor.authorRahman, W.
dc.contributor.authorMalek, R.
dc.date.accessioned2020-05-26T20:42:01Z
dc.date.available2020-05-26T20:42:01Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084448162&doi=10.14740%2fjem624&partnerID=40&md5=d4a9237f129d103497b838f245f65a2d
dc.identifier.urihttp://hdl.handle.net/10713/12843
dc.description.abstractThere is no established standard of care for the medical management of primary hyperparathyroidism in pregnancy for those patients who are not surgical candidates. We present a case of primary hyperpar-athyroidism in the third trimester that was managed with cinacalcet and a literature review on the various modalities for the medical management of primary hyperparathyroidism in pregnancy. The primary aim of this case report is to document a case of hyperparathyroidism in pregnancy that was managed medically and to perform a brief systematic review of the literature available on the medical management of primary hyperparathyroidism in pregnancy. The secondary aim is to contribute to the literature available on the use of cinacalcet in pregnancy. A 37-year-old woman with untreated primary hyperpar-athyroidism presented at 32 weeks of gestation with hypercalcemia that was not amenable to surgical intervention. We treated her with in-creasing doses of cinacalcet with improvement in her serum calcium until developing pre-eclampsia which prompted emergent cesarean delivery of the infant. The neonate developed respiratory distress after delivery but did not develop hypocalcemia after birth. The neonate became transiently hypercalcemic in the setting of calcium gluconate infusions given to prevent hypocalcemia. The patient underwent surgical removal of a parathyroid adenoma and required calcium sup-plementation for 1 month afterwards. Hypercalcemic crisis during pregnancy is associated with significant maternal and fetal morbidity. There is limited information regarding the medical management of primary hyperparathyroidism due to the lack of high-powered studies and prospective studies owing to the relative rarity of the condition. No serious adverse maternal events were reported for either bisphos-phonate or cinacalcet use. Adverse neonatal events include transient hypocalcemia of the infant with cinacalcet use and possibly low birth weight, infantile hypocalcemia, and shortened gestational periods with bisphosphonate use. Copyright The authors.en_US
dc.description.urihttps://doi.org/10.14740/jem624en_US
dc.language.isoen_USen_US
dc.publisherElmer Pressen_US
dc.relation.ispartofJournal of Endocrinology and Metabolism
dc.subjectBisphospho-nates pregnancyen_US
dc.subjectCinacalcet pregnancyen_US
dc.subjectHyperparathyroidism non-surgicalen_US
dc.subjectHyperparathyroidism pregnancyen_US
dc.subjectMedical management hyperparathyroidismen_US
dc.titleMedical management of primary hyperparathyroidism in pregnancy: A case report and brief literature reviewen_US
dc.typeArticleen_US
dc.identifier.doi10.14740/jem624


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