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dc.contributor.authorCannon, M.V.
dc.contributor.authorSerre, D.
dc.contributor.authorSà, J.M.
dc.date.accessioned2020-05-26T20:41:59Z
dc.date.available2020-05-26T20:41:59Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084783944&doi=10.1371%2fjournal.pbio.3000711&partnerID=40&md5=bb6f1889c5122f137391f0bbea3ae5c1
dc.identifier.urihttp://hdl.handle.net/10713/12836
dc.description.abstractPlasmodium vivax and P. falciparum, the parasites responsible for most human malaria worldwide, exhibit striking biological differences, which have important clinical consequences. Unfortunately, P. vivax, unlike P. falciparum, cannot be cultivated continuously in vitro, which limits our understanding of its biology and, consequently, our ability to effectively control vivax malaria. Here, we describe single-cell gene expression profiles of 9,215 P. vivax parasites from bloodstream infections of Aotus and Saimiri monkeys. Our results show that transcription of most P. vivax genes occurs during short periods of the intraerythrocytic cycle and that this pattern of gene expression is conserved in other Plasmodium species. However, we also identify a strikingly high proportion of species-specific transcripts in late schizonts, possibly associated with the specificity of erythrocyte invasion. Our findings provide new and robust markers of blood-stage parasites, including some that are specific to the elusive P. vivax male gametocytes, and will be useful for analyzing gene expression data from laboratory and field samples.en_US
dc.description.urihttps://doi.org/10.1371/journal.pbio.3000711en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS biology
dc.subjectspecies-specific transcriptsen_US
dc.subject.meshMalaria, Vivaxen_US
dc.subject.meshPlasmodium vivaxen_US
dc.subject.meshGene Expression Profilingen_US
dc.titleSingle-cell transcription analysis of Plasmodium vivax blood-stage parasites identifies stage- and species-specific profiles of expressionen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pbio.3000711
dc.identifier.pmid32365102


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