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dc.contributor.authorCao, T.
dc.contributor.authorMatyas, J.J.
dc.contributor.authorRenn, C.L.
dc.contributor.authorFaden, A.I.
dc.contributor.authorDorsey, S.G.
dc.contributor.authorWu, J.
dc.date.accessioned2020-05-26T20:41:57Z
dc.date.available2020-05-26T20:41:57Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084626464&doi=10.3390%2fcells9051194&partnerID=40&md5=3188e1cc1f5e37d0b514aafac0058310
dc.identifier.urihttp://hdl.handle.net/10713/12828
dc.description.abstractBrain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has been lauded for its pro-survival characteristics and involvement in both development and recovery of function within the central nervous system (CNS). However, studies of tyrosine receptor kinase B (TrkB), a major receptor for BDNF, indicate that certain effects of the TrkB receptor in response to disease or injury may be maladaptive. More specifically, imbalance among TrkB receptor isoforms appears to contribute to aberrant signaling and hyperpathic pain. A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental paradigms. Deletion of TrkB.T1 also limits astrocyte changes in vitro, including proliferation, migration, and activation. Mechanistically, TrkB.T1 is believed to act through release of intracellular calcium in astrocytes, as well as through interactions with neurotrophins, leading to cell cycle activation. Together, these studies support a potential role for astrocytic TrkB.T1 in hyperpathic pain and suggest that targeted strategies directed at this receptor may have therapeutic potential.en_US
dc.description.urihttps://doi.org/10.3390/cells9051194en_US
dc.language.isoen_USen_US
dc.publisherMDPI, AGen_US
dc.relation.ispartofCells
dc.subjectastrocytesen_US
dc.subjectbrain-derived neurotrophic factor (BDNF)en_US
dc.subjectneuropathic painen_US
dc.subjectspinal cord injuryen_US
dc.subjectTrkB.T1en_US
dc.subjecttyrosine receptor kinase B (TrkB)en_US
dc.titleFunction and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Painen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/cells9051194
dc.identifier.pmid32403409


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