Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain
MetadataShow full item record
AbstractBrain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has been lauded for its pro-survival characteristics and involvement in both development and recovery of function within the central nervous system (CNS). However, studies of tyrosine receptor kinase B (TrkB), a major receptor for BDNF, indicate that certain effects of the TrkB receptor in response to disease or injury may be maladaptive. More specifically, imbalance among TrkB receptor isoforms appears to contribute to aberrant signaling and hyperpathic pain. A truncated isoform of the receptor, TrkB.T1, lacks the intracellular kinase domain of the full length receptor and is up-regulated in multiple CNS injury models. Such up-regulation is associated with hyperpathic pain, and TrkB.T1 inhibition reduces neuropathic pain in various experimental paradigms. Deletion of TrkB.T1 also limits astrocyte changes in vitro, including proliferation, migration, and activation. Mechanistically, TrkB.T1 is believed to act through release of intracellular calcium in astrocytes, as well as through interactions with neurotrophins, leading to cell cycle activation. Together, these studies support a potential role for astrocytic TrkB.T1 in hyperpathic pain and suggest that targeted strategies directed at this receptor may have therapeutic potential.
brain-derived neurotrophic factor (BDNF)
spinal cord injury
tyrosine receptor kinase B (TrkB)
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084626464&doi=10.3390%2fcells9051194&partnerID=40&md5=3188e1cc1f5e37d0b514aafac0058310; http://hdl.handle.net/10713/12828
- Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury.
- Authors: Matyas JJ, O'Driscoll CM, Yu L, Coll-Miro M, Daugherty S, Renn CL, Faden AI, Dorsey SG, Wu J
- Issue date: 2017 Apr 5
- TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways.
- Authors: Wu J, Renn CL, Faden AI, Dorsey SG
- Issue date: 2013 Jul 24
- Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia.
- Authors: Wei X, Wang L, Hua J, Jin XH, Ji F, Peng K, Zhou B, Yang J, Meng XW
- Issue date: 2021 Apr 19
- Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.
- Authors: Fang X, Yang C, Li S, Zhan G, Zhang J, Huang N, Du X, Xu H, Hashimoto K, Luo A
- Issue date: 2020 Mar
- Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1.
- Authors: Holt LM, Hernandez RD, Pacheco NL, Torres Ceja B, Hossain M, Olsen ML
- Issue date: 2019 Aug 21