Neuroendocrine-Immune Crosstalk Shapes Sex-Specific Brain Development
PublisherOxford University Press
MetadataShow full item record
AbstractSex is an essential biological variable that significantly impacts multiple aspects of neural functioning in both the healthy and diseased brain. Sex differences in brain structure and function are organized early in development during the critical period of sexual differentiation. While decades of research establish gonadal hormones as the primary modulators of this process, new research has revealed a critical, and perhaps underappreciated, role of the neuroimmune system in sex-specific brain development. The immune and endocrine systems are tightly intertwined and share processes and effector molecules that influence the nervous system. Thus, a natural question is whether endocrine-immune crosstalk contributes to sexual differentiation of the brain. In this mini-review, we first provide a conceptual framework by classifying the major categories of neural sex differences and review the concept of sexual differentiation of the brain, a process occurring early in development and largely controlled by steroid hormones. Next, we describe developmental sex differences in the neuroimmune system, which may represent targets or mediators of the sexual differentiation process. We then discuss the overwhelming evidence in support of crosstalk between the neuroendocrine and immune systems and highlight recent examples that shape sex differences in the brain. Finally, we review how early life events can perturb sex-specific neurodevelopment via aberrant immune activation.
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084578824&doi=10.1210%2fendocr%2fbqaa055&partnerID=40&md5=59101328f6400fd6a375ca13029d8052; http://hdl.handle.net/10713/12824
- The immune system as a novel regulator of sex differences in brain and behavioral development.
- Authors: Nelson LH, Lenz KM
- Issue date: 2017 Jan 2
- Luteinizing hormone-releasing hormone (LHRH) receptors in the neuroendocrine-immune network. Biochemical bases and implications for reproductive physiopathology.
- Authors: Marchetti B, Gallo F, Farinella Z, Romeo C, Morale MC
- Issue date: 1996 Apr 30
- Neuroendocrine-immune circuits, phenotypes, and interactions.
- Authors: Ashley NT, Demas GE
- Issue date: 2017 Jan
- [Interaction involving the thymus and the hypothalamus-pituitary axis, immunomodulation by hormones].
- Authors: Marković L
- Issue date: 2004 May-Jun
- [Is the immune system our sixth sense? Relation between the immune and neuroendocrine systems].
- Authors: Ferencík M, Stvrtinová V
- Issue date: 1997 Apr