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dc.contributor.authorCroxton, T.
dc.contributor.authorAgala, N.
dc.contributor.authorAbimiku, A.
dc.date.accessioned2020-05-18T19:43:54Z
dc.date.available2020-05-18T19:43:54Z
dc.date.issued2020
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084304930&doi=10.4102%2fajlm.v9i1.935&partnerID=40&md5=97d6a401bfbbc4a85667cce3ad195819
dc.identifier.urihttp://hdl.handle.net/10713/12765
dc.description.abstractBackground: The Institute of Human Virology Nigeria (IHVN) - Human Heredity and Health in Africa (H3Africa) Biorepository (I-HAB) seeks to provide high-quality biospecimens for research. This depends on the ability of clinical research sites (CRS) - who provide biospecimens - to operate according to well-established industry standards. Yet, standards are often neglected at CRSs located in Africa. Here, I-HAB reports on its four-pronged approach to empower CRSs to prepare high-quality biospecimens for research. Objectives: I-HAB sought (1) to assess a four-pronged approach to improve biobanking practices and sample quality among CRSs, and (2) to build human capacity. Methods: I-HAB partnered with two H3Africa principal investigators located in Nigeria and Ghana from August 2013 through to May 2017 to debut its four-pronged approach (needs assessment, training and mentorship, pilot, and continuous quality improvement) to empower CRSs to attain high-quality biospecimens. Results: Close collaborations were instrumental in establishing mutually beneficial and lasting relationships. Improvements during the 12 months of engagement with CRSs involved personnel, procedural, and supply upgrades. In total, 51 staff were trained in over 20 topics. During the pilot, CRSs extracted 50 DNA biospecimens from whole blood and performed quality control. The CRSs shipped extracted DNA to I-HAB and I-HAB that comparatively analysed the DNA. Remediation was achieved via recommendations, training, and mentorship. Preanalytical, analytical and post-analytical processes, standard operating procedures, and workflows were systematically developed. Conclusion: Partnerships between I-HAB and H3Africa CRSs enabled research sites to produce high-quality biospecimens through needs assessment, training and mentorship, pilot, and continuous monitoring and improvement. Copyright: 2020. The Authors.en_US
dc.description.sponsorshipThe research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under award numbers UH2HG007008 and UH3HG007008.en_US
dc.description.urihttps://doi.org/10.4102/ajlm.v9i1.935en_US
dc.language.isoen_USen_US
dc.publisherAOSIS OpenJournals Publishing AOSIS (Pty) Ltden_US
dc.relation.ispartofAfrican Journal of Laboratory Medicine
dc.subjectAfricaen_US
dc.subjectBiobanken_US
dc.subjectBiotechnologyen_US
dc.subjectDeveloping countryen_US
dc.subjectTrainingen_US
dc.titleH3Africa partnerships to empower clinical research sites to generate high-quality biological samplesen_US
dc.typeArticleen_US
dc.identifier.doi10.4102/ajlm.v9i1.935


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