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    H3Africa partnerships to empower clinical research sites to generate high-quality biological samples

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    Author
    Croxton, T.
    Agala, N.
    Abimiku, A.
    Date
    2020
    Journal
    African Journal of Laboratory Medicine
    Publisher
    AOSIS OpenJournals Publishing AOSIS (Pty) Ltd
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.4102/ajlm.v9i1.935
    Abstract
    Background: The Institute of Human Virology Nigeria (IHVN) - Human Heredity and Health in Africa (H3Africa) Biorepository (I-HAB) seeks to provide high-quality biospecimens for research. This depends on the ability of clinical research sites (CRS) - who provide biospecimens - to operate according to well-established industry standards. Yet, standards are often neglected at CRSs located in Africa. Here, I-HAB reports on its four-pronged approach to empower CRSs to prepare high-quality biospecimens for research. Objectives: I-HAB sought (1) to assess a four-pronged approach to improve biobanking practices and sample quality among CRSs, and (2) to build human capacity. Methods: I-HAB partnered with two H3Africa principal investigators located in Nigeria and Ghana from August 2013 through to May 2017 to debut its four-pronged approach (needs assessment, training and mentorship, pilot, and continuous quality improvement) to empower CRSs to attain high-quality biospecimens. Results: Close collaborations were instrumental in establishing mutually beneficial and lasting relationships. Improvements during the 12 months of engagement with CRSs involved personnel, procedural, and supply upgrades. In total, 51 staff were trained in over 20 topics. During the pilot, CRSs extracted 50 DNA biospecimens from whole blood and performed quality control. The CRSs shipped extracted DNA to I-HAB and I-HAB that comparatively analysed the DNA. Remediation was achieved via recommendations, training, and mentorship. Preanalytical, analytical and post-analytical processes, standard operating procedures, and workflows were systematically developed. Conclusion: Partnerships between I-HAB and H3Africa CRSs enabled research sites to produce high-quality biospecimens through needs assessment, training and mentorship, pilot, and continuous monitoring and improvement. Copyright: 2020. The Authors.
    Sponsors
    The research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under award numbers UH2HG007008 and UH3HG007008.
    Keyword
    Africa
    Biobank
    Biotechnology
    Developing country
    Training
    Identifier to cite or link to this item
    https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084304930&doi=10.4102%2fajlm.v9i1.935&partnerID=40&md5=97d6a401bfbbc4a85667cce3ad195819; http://hdl.handle.net/10713/12765
    ae974a485f413a2113503eed53cd6c53
    10.4102/ajlm.v9i1.935
    Scopus Count
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