Genomics of Otitis Media (OM) Molecular Genetics Approaches to Characterize Disease Pathophysiology
JournalFrontiers in Genetics
PublisherFrontiers Media S.A.
MetadataShow full item record
AbstractOtitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical procedures necessary for its management. Although several studies provided evidence of genetics playing a significant role in the susceptibility to OM, we had limited knowledge about the genes associated with OM until recently. Here we have summarized the known genetic factors that confer susceptibility to various forms of OM in mice and in humans and their genetic load, along with associated cellular signaling pathways. Spotlighted in this review are fucosyltransferase (FUT) enzymes, which have been implicated in the pathogenesis of OM. A comprehensive understanding of the functions of OM-associated genes may provide potential opportunities for its diagnosis and treatment. Copyright 2020 The Authors.
SponsorsNational Institutes of Health/NIDCD R01DC016295, R01DC012564
Identifier to cite or link to this itemhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85084360242&doi=10.3389%2ffgene.2020.00313&partnerID=40&md5=ae7b7ed140ffca6f5244391294c1c8ff; http://hdl.handle.net/10713/12764