The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke
Date
2020Journal
Human Brain MappingPublisher
John Wiley and Sons Inc.Type
Article
Metadata
Show full item recordAbstract
The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided. Copyright 2020 The Authors.Identifier to cite or link to this item
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083706027&doi=10.1002%2fhbm.25015&partnerID=40&md5=4b72fb5d5d63c45176de002f51f27241; http://hdl.handle.net/10713/12718ae974a485f413a2113503eed53cd6c53
10.1002/hbm.25015