Sex chromosome evolution in parasitic nematodes of humans
| dc.contributor.author | Foster, J.M. | |
| dc.contributor.author | Mattick, J. | |
| dc.contributor.author | Dunning Hotopp, J.C. | |
| dc.date.accessioned | 2020-05-08T20:13:21Z | |
| dc.date.available | 2020-05-08T20:13:21Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083815566&doi=10.1038%2fs41467-020-15654-6&partnerID=40&md5=47b44a5c7ecc355d916f0106fe9231f1 | |
| dc.identifier.uri | http://hdl.handle.net/10713/12705 | |
| dc.description.abstract | Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution. Copyright 2020, The Author(s). | en_US |
| dc.description.sponsorship | This project was in part funded by the Burroughs-Wellcome Fund; federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under grant number U19 AI110820; the Medical Research Council grant MR/L001020/1, and Wellcome grant 098051. | en_US |
| dc.description.uri | https://doi.org/10.1038/s41467-020-15654-6 | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Nature Research | en_US |
| dc.relation.ispartof | Nature Communications | |
| dc.subject | evolutionary genetics | en_US |
| dc.subject | parasite genomics | en_US |
| dc.subject.mesh | Nematoda | en_US |
| dc.subject.mesh | Sex Chromosomes | en_US |
| dc.subject.mesh | Sex Determination Processes | en_US |
| dc.title | Sex chromosome evolution in parasitic nematodes of humans | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1038/s41467-020-15654-6 | |
| dc.identifier.pmid | 32327641 |